NIOSH Centers of Excellence for Total Worker Health® (U19)
UpcomingCenters for Disease Control and Prevention - ERA · Opportunity number RFA-OH-27-049 · Forecast
Closing date explanation: October 05, 2027. All applications must be submitted no later than 11:59 pm local time of the applicant's organization.
Eligibility
Nonprofits are listed as eligible applicants.
- Independent school districts
- Public housing authorities/Indian housing authorities
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- City or township governments
- State governments
- Native American tribal governments (Federally recognized)
- Small businesses
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- Private institutions of higher education
- Public and state controlled institutions of higher education
- County governments
- For profit organizations other than small businesses
- Special district governments
- Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the HHS Grants Policy Statement, are not allowed.
Description
PURPOSE NIOSH intends to support the Centers of Excellence in Total Worker Health® (TWH). These Centers will conduct rigorous research and translation activities to prevent harmful exposures, improve working conditions, and advance worker well-being. The Centers will develop practical, scalable solutions for employers and workers. All projects must use the NIOSH Worker Well-Being Questionnaire (WellBQ) and share data with the HERO Worker Well-Being Clearinghouse. Large Research Projects require economic evaluation. PRIORITY AREAS • High-risk occupations: First responders, vehicle mechanics, and technicians, with emphasis on occupational exposures, related health risks, and prevention strategies • Young workers, SMEs • Chronic disease • Mental health, stress • Substance use disorder • Artificial intelligence (AI), digital technologies This is a multi-component NOFO. COMPONENT STRUCTURE Percentages indicate maximum share of total budget. Overall Component (Required) Provides Center leadership and integration. Applicants should show strong coordination, scientific direction, and alignment across projects. Administration, Evaluation, and Emerging Issues Core (Required; up to 15%) Supports management and Center-wide evaluation. Applicants should describe oversight, data governance, and quality assurance.Optional activities include emerging issues and shared research resources. Outreach, Dissemination, and Impact Core (Required; up to 15%) Supports communication, worker/employer engagement, training, translation, implementation, and dissemination strategies. Research Projects (Required; about 60 to 70%) Includes all research activities. Applicants may propose a mix of projects. Research project distinctions are based on scope and complexity rather than cost. Projects should demonstrate scientific rigor and potential for sustained impact.
• Small Research Projects (Required; at least one project; up to 3 years) Exploratory, feasibility, early-stage intervention, surveillance, or measurement studies. Priority areas: high-risk occupations, young workers, SMEs. Should show innovation and potential to expand.
• Large Research Projects (Required; at least one project; up to 5 years) Multiyear etiologic, mechanistic, intervention, or translational studies. Priority areas: chronic disease, mental health, substance use disorder. Economic evaluation is required. Projects should include strong design and analytic plans.
• Pilot/Feasibility Program (Optional; 12–18 months) Short-term studies generating preliminary data or testing AI/digital technology approaches.
Funding
| Total program funding | $58,500,000 |
|---|---|
| Award floor | $500,000 |
| Award ceiling | $1,400,000 |
| Category | Health |
| Assistance listing | 93.262 |
Official sources
Last verified on Grants.gov Nov 4, 2026. Grantvello is not affiliated with Grants.gov or Centers for Disease Control and Prevention - ERA. The notice on Grants.gov is the binding text.