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Transformative Technologies for Experimental and Computational RNome Characterization and Functional Analysis

Upcoming

National Institutes of Health · Opportunity number RFA-RM-28-006 · Forecast

Expected postingOct 1, 2026
Closing dateFeb 15, 2027
Award ceiling$500,000
Expected awards10
From Grants.gov

Eligibility

Nonprofits are listed as eligible applicants.

  • City or township governments
  • Native American tribal governments (Federally recognized)
  • Private institutions of higher education
  • Public housing authorities/Indian housing authorities
  • For profit organizations other than small businesses
  • Small businesses
  • Independent school districts
  • Special district governments
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • County governments
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Public and state controlled institutions of higher education
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • State governments
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Description

The NIH Common Fund, in partnership with other NIH Institutes and Centers, plans to issue Notices of Funding Opportunity (NOFOs) for the RNomics program, which seeks to develop tools for studying the full set of RNA molecules (the RNome) in cells and tissues. The program will support technologies and resources that enable integrated analysis of RNA sequences, modifications, structures, locations, interactions, and functions to advance understanding of health and disease. RNomics includes four initiatives: technology enhancement centers, transformative technologies, molecular standards, and a coordinating center. Applications are not being solicited at this time. This notice is being provided to give potential applicants time to develop meaningful collaborations and strong projects. This NOFO will support the transformative technologies initiative. These phased projects will develop new experimental and computational RNA technologies that address major limitations of current methods. Projects will focus on early-stage, high-risk ideas not yet demonstrated at scale or in biologically relevant systems. Priority areas include tools to sequence RNA, detect modifications, study RNA function, and analyze RNA across molecules, cells, and tissues. Projects that successfully complete Phase 1 milestones will be evaluated for transition to Phase 2. Phase 2 projects are expected to deliver validated tools for community use.

Funding

Total program funding$8,000,000
Award floorNot listed
Award ceiling$500,000
CategoryHealth
Assistance listing93.310

Official sources

Last verified on Grants.gov Nov 4, 2026. Grantvello is not affiliated with Grants.gov or National Institutes of Health. The notice on Grants.gov is the binding text.