Federal grant opportunities open to nonprofits

Grants.gov listings that name nonprofits as eligible applicants. We re-check every listing daily and mark an opportunity Open only when Grants.gov confirmed it within the last 48 hours.

816 open, 304 upcoming · last checked Nov 5, 2026 · 1,120 shown by this search.

• NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

  National Institutes of Health · PA-25-306

  Open
  Closes Jan 7, 2028

• Advancing Healthcare for Older Adults from Populations that Experience Health Disparities (R01 - Clinical Trial Optional)

  National Institutes of Health · PAR-24-273

  Open
  Closes Jan 7, 2028

• Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)

  National Institutes of Health · PAR-25-287

  Open
  Closes Jan 7, 2028

• Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)

  National Institutes of Health · PAR-25-206

  Open
  Closes Jan 7, 2028

• NCMRR Early Career Research Award (R03 Clinical Trial Optional)

  National Institutes of Health · PAR-25-124

  Open
  Closes Jan 7, 2028 Award up to $200,000 Program total $200K

• NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

  National Institutes of Health · PA-25-301

  Open
  Closes Jan 7, 2028

• NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

  National Institutes of Health · PA-25-304

  Open
  Closes Jan 7, 2028

• DoW’s Energy, Installations, and Environment Innovation Partners Programs

  Washington Headquarters Services · HQ003423NFOEASD07

  Open
  Closes Jan 8, 2028 Award up to $100,000,000

• Stimulating Access to Research in Residency (StARR) (R38 Independent Clinical Trial Not Allowed)

  National Institutes of Health · RFA-HL-26-012

  Open
  Closes Jan 10, 2028

• Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed)

  National Institutes of Health · PAR-26-106

  Open
  Closes Jan 25, 2028 Award up to $8,000,000 Program total $88M

• Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

  National Institutes of Health · PAR-25-383

  Open
  Closes Jan 28, 2028

• Commercial Fishing Occupational Safety Training Project Grants (T03)

  Centers for Disease Control and Prevention - ERA · RFA-OH-22-006

  Open
  Closes Jan 31, 2028 Award up to $975,000 Program total $3M

• Commercial Fishing Occupational Safety Research Cooperative Agreement (U01)

  Centers for Disease Control and Prevention - ERA · RFA-OH-22-005

  Open
  Closes Jan 31, 2028 Award up to $975,000 Program total $3M

• Fiscal Year 2026 Flood Mitigation Assistance Swift Current

  Department of Homeland Security - FEMA · DHS-26-MT-144-000-99

  Open
  Closes Jan 31, 2028 Program total $600M

• Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)

  Food and Drug Administration · RFA-FD-25-017

  Open
  Closes Feb 8, 2028 Award up to $600,000

• NDEP STEM Open NFO

  Washington Headquarters Services · HQ003423NFOEASD01

  Open
  Closes Feb 8, 2028 Award up to $10,000,000

• WaterSMART Cooperative Watershed Management Program

  Bureau of Reclamation · R26AS00349

  Open
  Closes Feb 15, 2028 Award up to $300,000 Program total $25M

• Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

  National Institutes of Health · PAR-25-442

  Open
  Closes Feb 17, 2028

• Research on System Support and Tools for Provider Training and Quality Monitoring for Suicide Preventive Care (RP1- Clinical Trial Optional)

  National Institutes of Health · RFA-MH-28-145

  Open
  Closes Feb 17, 2028 Program total $3M

• Environmental influences on Child Health Outcomes (ECHO) Cohort Data and Biospecimen Access (X01 Clinical Trial Not Allowed)

  National Institutes of Health · PAR-25-437

  Open
  Closes Mar 1, 2028

Source: Grants.gov. Grantvello is not affiliated with Grants.gov or any federal agency. Always read the full notice of funding opportunity on Grants.gov before applying.