Federal grant opportunities open to nonprofits

Grants.gov listings that name nonprofits as eligible applicants. We re-check every listing daily and mark an opportunity Open only when Grants.gov confirmed it within the last 48 hours.

816 open, 304 upcoming · last checked Nov 5, 2026 · 1,120 shown by this search.

• BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-DC-27-004

  Open
  Closes Feb 11, 2027 Award up to $700,000 Program total $6M

• EMERGING FRONTIERS IN RESEARCH AND INNOVATION (EFRI-2026/27): Wave-Based Computing ( EFRI-WBC)

  U.S. National Science Foundation · 26-524

  Open
  Closes Feb 11, 2027 Program total $30M

• Accelerating Research and Development of Next Generation Vaccines against Malaria - a Model for Mosquito-Borne Diseases (R61/R33 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-AI-28-024

  Open
  Closes Feb 11, 2027 Program total $4M

• Limited Competition: Biospecimen Banks to support NCI National Clinical Trials Network Biospecimen Banks (NCTN Biobanks) and the NCI Early-Phase and Experimental Clinical Trials Biospecimen Bank (EET Biobank) (U24 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-CA-28-004

  Open
  Closes Feb 11, 2027 Program total $19M

• NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)

  National Institutes of Health · RFA-LM-28-001

  Open
  Closes Feb 11, 2027 Award up to $775,000 Program total $17.1M

• Advancing coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management.

  DOC NOAA - ERA Production · NOAA-NOS-NCCOS-2026-32934

  Open
  Closes Feb 12, 2027 Award up to $2,000,000 Program total $2M

• Advancing Global Health

  Bureau of Global Health Security and Diplomacy · DFOP0017890

  Open
  Closes Feb 14, 2027 Award up to $250,000,000 Program total $2.1B

• NSF Dynamic Language Infrastructure - NEH Documenting Endangered Languages (DLI-DEL)

  U.S. National Science Foundation · 22-615

  Open
  Closes Feb 16, 2027 Program total $4.8M

• Systems Biology of Infection and Inflammation in Chronic Diseases (U19 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-AI-28-014

  Open
  Closes Feb 18, 2027 Award up to $2,500,000 Program total $26M

• Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)

  National Institutes of Health · RFA-HG-25-009

  Open
  Closes Feb 26, 2027

• Fiscal Year 2026 Flood Mitigation Assistance

  Department of Homeland Security - FEMA · DHS-26-MT-029-000-98

  Open
  Closes Feb 26, 2027 Program total $400M

• Accelerating Discovery through Partnered Research with All of Us to Analyze Participant Biospecimens (X01 Clinical Trial Not Allowed)

  National Institutes of Health · PAR-27-069

  Open
  Closes Mar 1, 2027

• Mid-Career Advancement (MCA)

  U.S. National Science Foundation · 22-603

  Open
  Closes Mar 1, 2027 Program total $18M

• Pathways to Enable Secure Open-Source Ecosystems (PESOSE)

  U.S. National Science Foundation · 26-506

  Open
  Closes Mar 2, 2027 Program total $40M

• NSF Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM)

  U.S. National Science Foundation · 25-514

  Open
  Closes Mar 2, 2027 Award up to $5,000,000 Program total $120M

• NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

  National Institutes of Health · PAR-25-141

  Open
  Closes Mar 4, 2027

• High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

  National Institutes of Health · RFA-DA-25-060

  Open
  Closes Mar 5, 2027 Award up to $1,500,000

• Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

  National Institutes of Health · PAR-27-081

  Open
  Closes Mar 5, 2027

• Coordinating Center for National Resource Network for the Study of Human Auditory and Vestibular Disorders (U24 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-DC-28-002

  Open
  Closes Mar 5, 2027 Award up to $200,000 Program total $300K

• The NIDDK Disorders of Gastrointestinal Interoception Consortium (DGIC) Scientific Data Research Center (U24 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-DK-28-214

  Open
  Closes Mar 5, 2027 Award up to $950,000 Program total $1.5M

Source: Grants.gov. Grantvello is not affiliated with Grants.gov or any federal agency. Always read the full notice of funding opportunity on Grants.gov before applying.