Federal grant opportunities open to nonprofits

Grants.gov listings that name nonprofits as eligible applicants. We re-check every listing daily and mark an opportunity Open only when Grants.gov confirmed it within the last 48 hours.

816 open, 304 upcoming · last checked Nov 5, 2026 · 1,120 shown by this search.

• Fiscal Year 2027 Teams Engaging Affiliated Museums and Informal Institutions (TEAM II) STEM Innovator

  National Aeronautics and Space Administration · NNH27ZHA002C

  Open
  Closes Feb 1, 2027 Award up to $250,000 Program total $4M

• Mathematical Sciences Infrastructure Program

  U.S. National Science Foundation · PD-20-1260

  Open
  Closes Feb 2, 2027

• Science and Technology Studies (STS)

  U.S. National Science Foundation · 22-629

  Open
  Closes Feb 2, 2027 Program total $6.2M

• NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)

  National Institutes of Health · PAR-25-026

  Open
  Closes Feb 3, 2027

• NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)

  National Institutes of Health · PAR-25-025

  Open
  Closes Feb 3, 2027 Award up to $1,515,000

• Computer and Information Science and Engineering (CISE): Future Computing Research (Future CoRe)

  U.S. National Science Foundation · 25-543

  Open
  Closes Feb 4, 2027 Award up to $12,000,000 Program total $280M

• State Process for Informing Consumers of Recalls Program

  National Highway Traffic Safety Administration · NHTSA-693JJ927R000007-FY27

  Open
  Closes Feb 4, 2027 Award up to $1,500,000 Program total $1.5M

• ROSES 2025: B.8 Heliophysics Spaceflight Science Foundations

  NASA Headquarters · NNH25ZDA001N-SSF

  Open
  Closes Feb 5, 2027

• BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-MH-26-170

  Open
  Closes Feb 8, 2027

• Mid-scale Research Infrastructure-1

  U.S. National Science Foundation · 24-598

  Open
  Closes Feb 8, 2027 Award up to $19,999,999 Program total $100M

• GROWING CONVERGENCE RESEARCH (GCR)

  U.S. National Science Foundation · 24-527

  Open
  Closes Feb 8, 2027 Award up to $3,600,000 Program total $16M

• Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-DA-28-013

  Open
  Closes Feb 8, 2027 Program total $4M

• Grid Supply Chain Alternatives to Lead Energy Dominance (SCALED)

  National Energy Technology Laboratory · DE-FOA-0003641

  Open
  Closes Feb 8, 2027 Award up to $237,000,000 Program total $237M

• Climate Program Office FY 2027 - Super Intelligence/Machine Learning Innovation to Advance NOAA's Earth System Science and Support Hazard Resilience

  DOC NOAA - ERA Production · NOAA-OAR-CPO-2027-33392

  Open
  Closes Feb 9, 2027 Award up to $750,000

• A Science of Science Approach to Analyzing and Innovating the Biomedical Research Enterprise (SoS:BIO)

  U.S. National Science Foundation · 23-569

  Open
  Closes Feb 9, 2027 Award up to $250,000 Program total $2M

• Carcinogen Hazard Assessment Monographs Program (CHAMP) (R01 Clinical Trial Not Allowed)

  National Institutes of Health · RFA-CA-28-013

  Open
  Closes Feb 9, 2027 Award up to $700,000 Program total $800K

• Silvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)

  National Institutes of Health · RFA-DK-27-119

  Open
  Closes Feb 10, 2027 Award up to $750,000 Program total $4.8M

• Science of Learning and Augmented Intelligence (SL)

  U.S. National Science Foundation · PD-19-127Y

  Open
  Closes Feb 10, 2027

• NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)

  National Institutes of Health · PAR-24-269

  Open
  Closes Feb 11, 2027

• Public Health Crisis Response Cooperative Agreement

  Centers for Disease Control - OPHPR · CDC-RFA-TP22-2201

  Open
  Closes Feb 11, 2027 Award up to $5,000,000 Program total $500M

Source: Grants.gov. Grantvello is not affiliated with Grants.gov or any federal agency. Always read the full notice of funding opportunity on Grants.gov before applying.